Anenge ese mabasa akakosha emuviri wedu ane hukama kune akasiyana mhando dzemapuroteni. Isu tinoshandisa angangoita makumi matatu ezviuru mhando dzakasiyana dzemapuroteni mune edu maseru maitiro, rimwe nerimwe richiita rakatarisana basa.
Saka iyeye protein basa nenzira kwayo, inofanira kupetwa nenzira kwayo. Iko kupeta kweprotein kunoenderana nechetatu-hukuru iyo imwe neimwe yavanowana muchadenga, uye ichatiudzawo nezvebasa rayo. Nekudaro, mapuroteni ane fibrous anoratidza mune yavo chimiro helices uye tambo dzinozovatendera kuti vagadzire yakasungirirwa tambo dzinozoshanda seyakarongeka tsigiro yemasero nematukisi. Kune rimwe divi iyo mapuroteni epasi rose, Ivo vane zvivakwa zvakaita sekutendeuka nemabatiro anovabvumidza kuve neyakaumbika chimiro.
Kana kupeta kwepuroteni kusiri iko, izvi zvinogona kukanganisa mashandiro emagetsi pamatanho akasiyana. Zvinogona kuitika kuti puroteni iri mubvunzo yakadzikiswa uye haizadzise mashandiro ayo, kana kune rimwe divi mapuroteni akamonyororwa anogona kunamatira pamwe, uye zvisingadzokere shure kuita mafomu asina kukwana. Iyi ndiyo mamiriro enhamba huru yezvirwere zvinosanganisirwa pasi pezwi rekuti amyloidosis nepo zviyero zvichinzi maamyloid. Mienzaniso yezvirwere izvi inozivikanwa pathologies senge Alzheimer's chirwere, mhando II chirwere cheshuga, uye bovine spongiform encephalopathy (inonyatso kuzivikanwa seMad Cow chirwere).
Tichifunga kuti aya maunganidzwa akaiswa zvishoma nezvishoma, aine nguva yekukwirisa inogona kuve makore akati wandei, aya zvirwere zvinowanzo bata makore ekupedzisira, uye izvo zvinonyanya kubata varwere vezera repamberi.